Is there a risk associated with employing ARPReach to send bulk emails to the main company domain?

Is there a risk of my main company domain being affected if my bulk emails get blacklisted when using an ARPReach Gold License installed as a subdomain? Should I use a fresh domain for bulk emailing instead? How do SMTP services like SendGrid and Amazon SES work in this context, and will they still affect my web hosting IP address and domain? I am new to this and would really appreciate clarification. Thank you for your time. Regards